Ion-channel sensors can be used for detection of biochemical reagents. A silicon-based ion-channel platform has been developed for stochastic sensing of molecules. In this project, we develop techniques to classify signals from ion channels to detect the presence of binding molecules or ions. The J-DSP graphical programming environment allows students to interactively manipulate and monitor the output of developed digital signal processing algorithms. Interactive exercises were developed to illustrate the pre-processing, information extraction and inference steps for analyzing these signals. The exercises were given to students at ASU in the graduate level Bio-sensors course. The developed exercises and the students pre- and post-exercise assessments of basic ion channel properties are presented here.

Figure 1: Walsh-Hadamard Tranform (WHT) based analysis of two ion-channel signals. The WHT point size can be set in the WHT dialogue box. The two signals show clear distinction in the transform domain